FOS Intake Improves Atherogenic Profile and Body Weight in Young Obese Adults of Urban Vadodara

23/12/2014

ABSTRACT Background and objectives: Recent nutrition research emphasizes the importance of prebiotics in health and disease. Several non-digestible but fermentable dietary carbohydrates may have the potential to regulate body weight and atherogenic profile in humans; however, the mechanisms for these changes are not fully understood. Methods: Using the double-blind placebo control trial design 72 obese adults aged 25-35 y were randomly selected from banks of urban Vadodara and further divided into control (n=32) and experimental group (n=40) who were supplemented with 20 g fructooligosaccharide and dextrose/day for 90 days respectively. Anthropometric profile, dietary intakes, hunger and satiety scores and atherogenic profile were determined using standard methods. Gut profile with respect to Bifidobacteria, Lactobacilli, Clostridium, and Bacteroides was determined using selective medium. Results: Post intervention results revealed that body weight, and percent body fat reduced significantly by 1.71% and 4.30% (p<0.001) respectively. The total mean satiety scores decreased by 7.74%. Improvement in atherogenic profile was observed in terms of reduced serum triglyceride levels by 22.82% followed by LDL cholesterol (16.55%) and TC (15.41%). FOS supplementation increased colonization of beneficial microflora in terms of bifidobacteria and lactobacilli significantly by 9.62% and 28.47% respectively whereas clostridium and bacteroides significantly reduced by 2.37% and 12.04% respectively. Conclusions: 20 g Fructooligosaccharide supplementation for 3 months reduced weight and improvised atherogenic profile of obese young adults which may have resulted due to altered gut microflora and improved satiety.

Jain, N., & Sheth, M. (2014). FOS intake improves atherogenic profile and body weight in young obese adults of Urban Vadodara. World Journal of Pharmaceutical Research, 4(1), 1094-09.